7-deaza-dGTP may be effectively incorporated into DNA by DNA polymerases and/or terminal deoxynucleotidyl transferase. 7-deaza-dG-containing DNA duplexes demonstrate increased stability. 7-deaza-dG-containing DNA penetrates cell membrane more effectively due to the increased lipophilicity.
7-deaza dGTP may be used in sequencing for resolution of compressions in G-C-rich regions. Amplification of some DNA regions is often hindered due to the high G-C content. Replacement of dGTP with 7-deaza dGTP in master mix may solve the problem.
Molecular formula: C11H13N4O13P3
Specification: |
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Tested for: |
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Format: |
10 mM sterile water solution of the ammonium salt. |
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